Immunotherapy for hematologic malignancies

The Minnie Lab is a tumor immunology lab with a focus on the differentiation of exhausted CD8 T cells in the bone marrow tumor microenvironment. We study multiple classes of immunotherapies, including antibodies, immunomodulatory drugs, adoptive cell therapies, and synthetic cytokines. Our mission is to leverage a mechanistic, hypothesis-driven approach to inform clinical translation of immunotherapies for patients. 

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Publications

Featured Publications

TIM-3+CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies
Simone A. Minnie, Olivia G. Waltner et al.
Science Immunology
2024 | Volume 9, eadg1094
TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice
Simone A. Minnie et al.
Journal of Clinical Investigation
2023 | Volume 133, Issue 4, e157907
Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity
Simone A. Minnie et al.
Science Immunology
2022 | Volume 7, eabo3420
Bone marrow transplantation generates T cell–dependent control of myeloma in mice
Slavica Vuckovic, Simone A. Minnie et al.
The Journal of Clinical Investigation
2019 | Volume 129, Issue 1, Pages 106-121
Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade
Simone A. Minnie et al.
Blood
2018 | Volume 132, Issue 16, Pages 1675-1688

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