UMAP embedding of exhausted CD8 T cells from mice with relapsed myeloma

IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCIES

The Minnie Lab is a tumor immunology lab with a focus on the differentiation of exhausted CD8 T cells in the bone marrow tumor microenvironment. We study multiple classes of immunotherapies, including antibodies, immunomodulatory drugs, adoptive cell therapies, and synthetic cytokines. Our mission is to leverage a mechanistic, hypothesis-driven approach to inform clinical translation of immunotherapies for patients. 

Our research

Publications

Publications

Featured Publications

2024
TIM-3+CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies Featured
Simone A. Minnie, Olivia G. Waltner et al.
Science Immunology
Volume 9, eadg1094
2023
TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice
Simone A. Minnie et al.
Journal of Clinical Investigation
Volume 133, Issue 4, e157907
2022
Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity
Simone A. Minnie et al.
Science Immunology
Volume 7, eabo3420
2019
Bone marrow transplantation generates T cell–dependent control of myeloma in mice
Slavica Vuckovic, Simone A. Minnie et al.
The Journal of Clinical Investigation
Volume 129, Issue 1, Pages 106–121
2018
Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade
Simone A. Minnie et al.
Blood
Volume 132, Issue 16, Pages 1675–1688

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